Top 50+ Solved Analgesics-Toxicology MCQ Questions Answer

a. The interval between ingestion and death is usually hours because of immediate pulmonary toxicity

b. Mechanism of action involves single electron oxidation of the herbicide to free radical species

c. Probable human lethal dosage is 50-500mg/kg

d. Oxygen high flow stops the pulmonary lesions occurring

e. Paraquat doesn’t affect hepatic or renal functions

a. Piroxicam has a half life of >50 hours

b. Aspirin reversibly inhibits COX

c. Diclofenac is a selective COX1 inhibitor

d. Indomethacin is relatively free of adverse side effects

e. Ibuprofen is predominantly excreted unchanged in the urine

a. Less than 5% is excreted unchanged

b. Acetaminophen has no anti-inflammatory properties

c. The half life of paracetamol is 2-3 hours

d. Haemolytic anaemia has rarely been noted with paracetamol

e. All of the above are true

a. Lead can induce an anaemia that is macrocytic

b. Young children absorb about 10% of ingested inorganic lead

c. Lead induced peripheral neuropathy often involves upper limb extensors resulting in wrist drop

d. High dose organic lead poisoning usually results in severe pneumonitis

e. All patients with elevated blood lead levels should have chelation treatment whether symptomatic or not

a. As little as 8mg of colchicine taken over 24 hours may be fatal

b. Allopurinol is a xanthine oxidase stimulator

c. Probenecid is an organic alkaline substance

d. Colchicine may precipitate acute attacks of gout

e. Aspirin is effective against gout as it inhibits urate crystal phagocytosis

a. Salivation

b. Tachycardia

c. Fibrillation of muscle fibres

d. Bronchospasm

e. Vomiting

a. The average anti-inflammatory dose of aspirin is 0.6g up to 4 hourly

b. Aspirin’s main side effect at usual doses is rash

c. Aspirin’s antiplatelet effect lasts 8 – 10 days

d. At low toxic doses – respiratory acidosis may occur

e. Aspirin has a pka of 4.5

a. Inhibition of polymorphonuclear leucocytes

b. Inhibition of synoviocyte phagocytosis

c. Reduced formation of leukotriene D4

d. Inhibition of mononuclear phagocytes

e. Decreasing the body pool of urate

a. Cyclo oxygenase

b. Recurrent miscarriages

c. Protacyclin synthesis

d. Kallikrein system

e. Lipo oxygenase

a. Deamination

b. N-oxidation

c. Glucuronidation

d. Sulphation

e. Glutathione conjugation

a. Is hydrolysed to acetone and salicylate

b. Exhibits first order kinetics with elimination in low doses

c. Is mostly conjugated by the liver and excreted in the bile

d. Reversibly blocks the cyclooxygenase enzyme

e. Causes an immediate doubling of bleeding time

a. At high doses diclofenac demonstrates zero order kinetics

b. Aspirin is a reversible inhibitor of cyclooxygenase

c. Aspirin at doses of <2g/day reduces uric acid levels

d. All NSAIDs can be found in synovial fluid after repeated dosing

e. Use of ibuprofen and aspirin together increases the anti inflammatory effect

a. Conjugation with glucuronide

b. Oxidation

c. Reduction

d. Cytochrome p-450 dependent glutathione conjugation

e. Methylation

a. Diclofenac

b. Naproxen

c. Piroxicam

d. Indomethacin

e. Ibuprofen

a. Tinnitus

b. Vasomotor collapse

c. Metabolic acidosis

d. Gastric intolerance

e. Renal failure