Top 250+ Solved Physical Pharmaceutics 2 MCQ Questions Answer
Q. Penicillin G is prepared as a salt of procaine penicillin G. Now the rate of decomposition of penicillinG will be:
a. increased
b. reduced
c. unchanged
d. unpredictable
Q. According to International Pharmaceutical Federation, the recommended overages be limited to themaximum percent of:
a. five
b. ten
c. thirty
d. twenty
Q. Usually, the rate of a chemical reaction may be enhanced by:
a. cooling the reaction mixture
b. increasing the rate of stirring
c. raising the temperature of the reaction mixture
d. using stoichiometric quantities of each reactant
Q. Which of the following expression is correct for the determination of shelf life for a first orderdecomposition?
a. t1/2 = 0.105/k
b. t90 = 0.693/k
c. t1/2 = 0.693/k
d. t90 = 0.105/k
Q. Regarding the influence of the solvent on the rate of reaction, solvents having the internal pressure:
a. HIGHER produce products with HIGHER internal pressure
b. HIGHER favour the formation of products having LOWER internal pressure
c. LOWER yield products having HIGHER internal pressure
d. LOWER retard the formation of products with LOWER internal pressure
Q. During autoclaving of dextrose solution, a straw colour is observed. It is due to the presence of asubstance called:
a. furfural
b. 5-hydroxymethylfurfural
c. 5-hydroxyfurfural
d. 5-methylfurfural
Q. In injections, procaine undergoes the degradation reactions in the following sequence:
a. decarboxylation and hydrolysis
b. hydrolysis and decarboxylation
c. hydrolysis, decarboxylation and oxidation
d. oxidation, decarboxylation and hydrolysis
Q. On a product, the label states ‘protect from light’. What type of decomposition does the productundergo?
a. carboxylation
b. decarboxylation
c. hydrolysis
d. oxidation
Q. Which of the following reactions is observed in the degradation of ampicillin?
a. decarboxylation
b. hydrolysis
c. oxidation
d. recimization
Q. Aspirin undergoes decomposition in a formulation. It can be prevented by:
a. adding a chelating agent
b. adding an antioxidant
c. protecting it from light
d. suppressing its solubility
Q. Which one of the following is primarily NOT a chemical decomposition?
a. isomerisation
b. hydrolysis
c. oxidation
d. volatilization
Q. For the validity of accelerated stability studies of solution dosage form, the energy of activationshould be in the range of (in units of kcal/mole).
a. 0 to 10
b. 11 to 30
c. 31 to 50
d. 51 to 70
Q. Which one of these methods is the MOST effective in preventing the rate of hydrolysis?
a. buffer
b. complexation
c. removal of water
d. suppression of solubility
Q. During storage, crystal growth is observed in a suspension due to:
a. absorption of water
b. fluctuations in the ambient temperatures
c. presence of suspending agent
d. volatilization of solids
Q. The storage directions on a parenteral solution specify ‘store in a cool place’. This may be stored in:
a. an air-conditioned area at 10°C
b. a refrigerator at 15°C
c. a place whose temperature is set at 5°C
d. room temperature, at 25°C