Top 50+ Solved Pharmacological Principles MCQ Questions Answer

From 1 to 15 of 17

Q. Which of the following drugs has an average half life of 50 hours?

a. Nortriptylline

b. Digoxin

c. Trimethoprim

d. Valproic acid

e. Lithium

  • b. Digoxin

Q. All of the following have 100% oral bioavailability EXCEPT

a. Valproic acid

b. Trimethoprim

c. Digoxin

d. Diazepam

e. Lithium

  • c. Digoxin

Q. All of the following drugs are >90% plasma protein bound EXCEPT

a. Diazepam

b. Frusemide

c. Fluoxetine

d. Gentamicin

e. Warfarin

  • d. Gentamicin

Q. All of the following drugs exhibit flow dependent elimination EXCEPT

a. Atenolol

b. Isoniazid

c. Propoxyphene

d. Amitriptylline

e. Lignocaine

  • a. Atenolol

Q. Which of the following undergoes a phase I hydrolysis reaction?(biotransformation)

a. Ethanol

b. Naloxone

c. Morphine

d. Lignocaine

e. Diazepam

  • d. Lignocaine

Q. Which of the following undergoes acetylation in the liver? (Phase 2 biotransformation)

a. Isoniazid

b. Acetaminophen

c. Salicylic acid

d. Epinephrine

e. Diazepam

  • a. Isoniazid

Q. A D Response B C Concentration Which of these drugs is the most efficacious?

a. Drugs A and B

b. Drug C

c. Drugs A and D

d. Drugs D and C

e. Drug A

  • c. Drugs A and D

Q. EC50 is

a. Measured with a radioactive receptor

b. Always equal to Kd

c. Drug concentration with 50% receptors bound

d. Representation of the receptors affinity for drug binding

e. Drug concentration with 50% of maximal drug effect

  • e. Drug concentration with 50% of maximal drug effect

Q. Which of the following will NOT alter the volume of distribution of a drug?

a. Cardiac failure

b. Clearance

c. Age

d. Burns

e. Pleural effusion

  • b. Clearance

Q. Volume of distribution equals

a. Dose given/plasma concentration

b. Total amount of drug in the body/plasma concentration

c. Urine drug concentration/plasma concentration

d. Dose given/urine concentration

e. Urine drug concentration/plasma concentration

  • b. Total amount of drug in the body/plasma concentration

Q. Which of the following drugs undergoes rate limited elimination?

a. Lignocaine

b. Morphine

c. Warfarin

d. Propanolol

e. Aspirin

  • e. Aspirin

Q. Ligand gated channel receptors include all of the following EXCEPT

a. GABA

b. Aspartate

c. Glycine

d. Glutamate

e. Ach-muscarinic

  • e. Ach-muscarinic

Q. Regarding receptor regulation

a. Receptor down regulation occurs over hours – days

b. Receptor responses to drugs often “desensitise” with time – this desensitisation is usually irreversible

c. The mechanism of agonist induced desensitisation of the nicotinic Ach receptor has been worked out in detail

d. All “internalised” receptors are degraded by lysosomes

e. None of the above are correct

  • a. Receptor down regulation occurs over hours – days

Q. Which of the following acts on intracellular receptors

a. Serotonin

b. Glucagon

c. Corticosteroids

d. GABA

e. Insulin

  • c. Corticosteroids
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