Top 50+ Solved Pharmacokinetics - Pharmacodynamics MCQ Questions Answer
Q. Drugs that enhance other drug metabolism include all of the following EXCEPT
a. Rifampicin
b. Ketoconazole
c. Phenobarbital
d. Griseofulvin
e. Phenytoin
Q. Which is the safest to give in pregnancy?
a. Lithium
b. Phenytoin
c. Gentamycin
d. Heparin
e. ACE inhibitors
Q. Regarding pharmacology principles
a. Diffusion is directly proportional to thickness and inversely proportional to surface area
b. LD50 - 50% of the dose that kills most people
c. Efficacy is the maximum response produced by a drug
d. A partial agonist is always less potent than a full agonist
e. EC50 = concentration of agonist that results in maximal response in 50% of patients
Q. Reports of cardiac arrhythmias caused by unusually high blood levels of 2 antihistamines (terfenadine and astemizole) are best explained by
a. Concomitant treatment with phenobarbital
b. Use of these drugs by smokers
c. Use of antihistamines by persons of Asian background
d. A genetic predisposition to metabolise succinylcholine slowly
e. Treatment of these patients with ketoconazole
Q. Which of the following statements is correct?
a. The half life is the time taken for a parameter to fall to 1/4 its original value
b. Partial agonists act at receptor sites to cause maximal pharmacological effect at high doses
c. Diazepam has a high extraction ratio and is thus subject to flow dependent elimination
d. Morphine and pethidine have the same potency
e. A patient with oedema will have an increased volume of distribution of tobramycin