Q. Which of the following statements is correct? (Solved)

1. The half life is the time taken for a parameter to fall to 1/4 its original value

2. Partial agonists act at receptor sites to cause maximal pharmacological effect at high doses

3. Diazepam has a high extraction ratio and is thus subject to flow dependent elimination

4. Morphine and pethidine have the same potency

5. A patient with oedema will have an increased volume of distribution of tobramycin