Top 150+ Solved Dosage Form Design 2 MCQ Questions Answer
Q. Half life (t1/2) is the time required to:
a. change the amount of a drug in plasma by half during elimination
b. metabolize a half of an introduced drug into the active metabolite
c. absorb a half of an introduced drug
d. bind a half of an introduced drug to plasma proteins
Q. Half life (t1/2) does not depend on:
a. biotransformation
b. time of drug absorption
c. concentration of a drug in plasma
d. rate of drug elimination
Q. Elimination rate constant (Kelim) is defined by the following parameter:
a. rate of absorption
b. maximal concentration of a substance in plasma
c. highest single dose
d. half life (t1/2)
Q. Systemic clearance (Cl) is related with:
a. only the concentration of substances in plasma
b. only the elimination rate constant
c. volume of distribution, half life and elimination rate constant
d. bioavailability and half life
Q. Biological Half life equation for first order process is
a. t1/2 = a/2K
b. t1/2 = 0.693/K
c. t1/2 = 1/aK
d. t1/2 = 3/2 K
Q. The area under the serum concentration time curve of the drug represents:
a. the biological half life of the drug
b. the amount of drug in the original dosage form
c. The amount of drug absorbed
d. The amount of drug excreted in the urine
Q. Drug having ……..half-lives take a very short time to achieve plateau concentration.
a. shorter
b. longer
c. intermediate
d. none of the above
Q. The primary pharmacokinetic parameter clearance can be calculated by
a. Cl = KV
b. Cl = Dose/AUC
c. Cl = (dA/dt)/C
d. all of the above
Q. ………..change in drug kinetics is known as chronokinetics.
a. Time-dependent
b. Dose-dependent
c. Both (a) & (b)
d. None of the above
Q. Constant rate infusion prevents………..in blood levels.
a. fluctuations
b. peak maximum
c. valley minimum
d. all of the above
Q. Constant rate infusion is……..
a. prevents fluctuations
b. useful when drug has narrow TI
c. Both (a) & (b)
d. none of the above
Q. Concentration of drug at peak is known as …………drug concentration.
a. maximum
b. minimum
c. lower
d. none of the above
Q. In one compartment open model, the term open indicates input and output is:
a. unidirectional
b. bidirectional
c. non-directional
d. none of the above
Q. The mathematical relationship between plasma drug concentration and pharmacological response iscalled as………..
a. PK modeling
b. PD modeling
c. PK-PD modeling
d. None of the above
Q. The ratio of maximum safe concentration to minimum effective concentration is called as
a. Therapeutic index
b. Therapeutic range
c. Therapeutic outcome
d. Therapeutic ratio