Top 50+ Solved Drug Stability - Chemical Kinetics MCQ Questions Answer
Q. In the photochemical degradation of multisulpha preparation, the order that the reaction follows is:
a. first
b. pseudo first
c. second
d. zero
Q. The integral equation (in common notation) k = x/at (a - x) is concerned with the order:
a. first
b. pseudo first
c. second
d. zero
Q. When a series of steps are involved in a reaction, the ‘overall rate’ of a reaction depends upon therate(s) of:
a. all steps
b. all steps which follow the slowest step
c. all steps which precede the slowest step
d. the slowest step
Q. The solid state decomposition of aspirin in presence of moisture follows the order:
a. first
b. pseudofirst
c. second
d. zero
Q. The reaction rate constant (k) is 2.0 x 10-3 min.-1 for aspirin hydrolysis in 0.1 N hydrochloric acid at1mg/ml concentration. Under same conditions, if the product contains aspirin 4 mg/ml of the initial concentration, the k value in minutes-1 will be:
a. 0.5 x l0-3
b. 2.0 x 10-3
c. 4.0 x 10-3
d. 8.0 x 10-3
Q. A second order reaction follows pseudo-first order reaction, when the concentrations of:
a. two reactants are high
b. two reactants are low
c. one reactant is far higher than the other reactant.
d. two reactants are equal
Q. In the study of the rate of a reaction, 100 ml of 0.1 N hydrochloric acid is added to 10 ml methylacetate for the reaction to occur. The reason for making such a proportion is to make:
a. analysis of degradation is easy
b. reaction to follow first order
c. reaction to proceed slowly
d. reaction to undergo a pseudo first order
Q. The conversion of trans-stilbene to cis-stilbene follows the molecularity:
a. bimolecular
b. termolecular
c. unimolecular
d. zeromolccular
Q. In the hydrolysis of sucrose in hydrochloric acid solution, the change in the optical rotation followsthe order:
a. pseudofirst
b. pseudo zero
c. second
d. zero
Q. In the degradation studies of aspirin suspension, the orders observed initially and at the end,respectively, are: -
a. first, second
b. first, zero
c. second, first
d. zero, first
Q. A prescription of liquid aspirin preparation contained 6.5 g/100 ml. The solubility of aspirin at 25°Cis 0.33 g/100 ml. The order of reaction in the kinetic study is:
a. apparent first
b. apparent zero
c. first
d. second
Q. The time required for the complete degradation of a drug in solution is a finite value. The order ofthat reaction is:
a. first
b. pseudo first
c. second
d. zero
Q. Normally, ethyl acetate undergoes hydrolysis in presence of H+and (OH)-ions. The order of the reaction observed in the acidic and alkaline solutions, respectively, are:
a. first and second
b. pseudo first and second
c. second and first
d. second and pseudo first
Q. In reactions that follow first order kinetics, half life is expressed by equation:
a. 0.693/k1
b. 0.301/k1
c. 0.105/k1
d. k1/0.693